Immunofluorescence staining of F-actin and cell area quantification Cells were fixed in 3. Contact angle measurements and protein adsorption Characterization of hydrophobicity was performed through static water contact angle measurements. As we can see from Figure 3the three blood proteins have drastically different adsorption patterns on the different surfaces. Abstract Understanding and modulating the cellular response to implanted biomaterials is crucial for the field of tissue engineering and regenerative medicine. The water contact angle measurements demonstrate that the presence of nanofeatures on the polystyrene and polypropylene thin films increases the contact angles. This result translates into a more globally hydrophobic surface. Methods 25, [ PubMed ].
The higher aspect ratio nanostructured substrates such as P 20 and P 5 have higher surface roughnesses, which may correspond to fewer cellular contact points for integrin engagement.
The Effect of Nanotopography on Modulating Protein Adsorption and the Fibrotic Response
Vi kunde inte hitta en exakt plats. Collagen consists of staggered arrays of tropocollagen molecules that bind together to form fibrils. Fibroblast signaling events in response to nanotopography: This result may be directly related to the surface structure or indirectly related to the way the surface topography influences ECM protein recruitment. Vi känner inte igen webbläsaren du använder.